Warfarin's much less strong R-enantiomer is metabolized partly by CYP3A4 (and in addition CYP1A2 and CYP2C19). Watch INR additional usually if coadministered with inhibitors of such isoenzymes and regulate warfarin dose if wanted.
posaconazole will increase the stage or effect of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
acetazolamide will increase the amount or result of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Not known.
Belzutifan is a CYP2C19 substrate. Coadministration with CYP2C19 inhibitors may possibly raise incidence or severity of adverse outcomes. Keep an eye on for anemia and hypoxia and lessen belzutifan dose as advisable.
300mg Armodafinil: Not automatically advised, Until you actually have to operate eighteen+ hours in a single working day with sound focus and target. This can be a double dose of Armodafinil, so move forward with warning. Break up dosing proposed throughout the day. Minor Unwanted effects frequent. No long-term risks.
Indicated to boost wakefulness in Older people with excessive sleepiness connected with shift perform dysfunction (SWD)
Modafinil is a stimulant medication that is generally Harmless, well-tolerated, and carries a small opportunity for abuse and dependence. It is utilized to treat excessive daytime sleepiness connected with narcolepsy, rest perform shift condition, and obstructive rest apnea. It is usually used in conjunction with other healthcare and Way of life remedies for these circumstances. Most individuals can safely receive modafinil, although it ought to be applied cautiously in clients with structural cardiac ailment, significant hepatic impairment, or a heritage of psychosis/mania.
Intrauterine progress restriction and spontaneous abortion have been described with modafinil and armodafinil
The success of steroidal contraceptives may be lowered when employed with PROVIGIL and for one particular thirty day period right after discontinuation of therapy. Choice or concomitant ways of contraception are proposed for patients taking steroidal contraceptives (e.
To be able to acquire a prescription for modafinil, a affected individual needs to have a sound health care basis for using the drug, which include narcolepsy or slumber apnea. Moreover, the prescription have to be prepared by a certified medical doctor and crammed at a licensed pharmacy. The use of modafinil for non-healthcare functions, like Using the aim to further improve cognitive effectiveness or to stay awake for extended amounts of time, is strictly prohibited and can lead to lawful repercussions.[a hundred seventy five][176] Europe[edit]
elvitegravir/cobicistat/emtricitabine/tenofovir DF increases amounts of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
Doses as many as four hundred mg/day, given as one dose, happen to be perfectly tolerated, but there is no dependable more information evidence this dose confers extra gain past that with the 200 mg/working day dose [see Scientific PHARMACOLOGY and Medical Experiments].
Though no unique monitoring is suggested for clients on modafinil, nurses, pharmacists, and physicians must know about the possible drug-drug interactions, which includes oral contraceptive supplements. That is why the prescriber must check with which has a pharmacist and perform a thorough evaluation of all current drugs. Nursing really should observe patient outcomes and in addition check for indications of adverse reactions at Every pay a visit to. This interprofessional strategy will optimize therapy with modafinil. [Level 5]
Although modafinil is made use of like a cognitive enhancer or "clever drug" amongst healthier individuals in search of enhanced concentrate and productiveness,[fourteen][fifteen] its use outdoors health care supervision raises concerns relating to probable misuse or abuse.